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The cycle structure exists for a practical reason: continuous stimulation of the same receptor pathways can lead to reduced sensitivity over time, and a rest period allows the system to reset before the next cycle produces full effect

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Food-cobalamin (vitamin B 12 ) malabsorption, first described by Carmel in 1995,30 is the most common cause of vitamin B 12 deficiency in the elderly and accounts for about 40% to 70% of cases.26 29 31 It is characterised by the inability to release vitamin B 12 from food or from its binding protein and thus, preventing vitamin B 12 from being taken up by intrinsic factor for absorption

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