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Figure 6 3.8 CB-839 did not improve cytotoxicity in combination with venetoclax, AZD-5991, and ibrutinib in primary CLL lymphocytes We then tested these drug combinations in the primary CLL cells, both in the native condition ( Figure 7A ) and in media supplemented with cytokines (CD40 ligand and interleukin-4) to mimic the microenvironment and maintain viability ( Figure 7B )

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Protein extraction and characterization A detailed description of our protein-related research methods, including extraction, proteomics analysis, liquid chromatography-mass spectrometry (LC-MS) analysis, database searching, criteria for identification, and quantitative proteomics, is provided in Supplementary Material

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