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In addition to needing long-term data in primary CV prevention populations, further research evaluating the CV effects of other GLP-1RA and SGLT2-I is required to understand whether such findings are agent or dose dependent

Quiets appetite signaling Acts on the brain's hunger pathways, reducing the constant food noise that drives unconscious overeating

H., & Visioli, F

The mechanistic explanation is not speculative: the glucagon receptor adds hepatic fatty-acid oxidation, adipose lipolysis and thermogenic energy expenditure that dual agonism cannot engage by design 27, and the Phase 2a MASLD readouts 8590% liver-fat reduction is a direct signature of that pathway 3