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Tirzepatide-Related Common GI Symptoms : Nausea, vomiting, diarrhea, and constipation are frequently reported

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Using the GLP-QR agonist Exendin-4 (Exn-4) increased firing rates in arcuate nucleus (ARC) GLP-1R and POMC neurons, and the chemogenetic activation of ARC GLP-1R neurons significantly reduced food intake [132]

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Sub-analyses examining the effect of background therapy when patients are randomized to receive the other vs