microdosing glp 1 for anxiety GLP-1 is popular, but there's little evidence it works Exploring The Gut-Brain Connection |

Reduced benefits: Using doses that are too low may limit benefit, while stopping or adjusting treatment without follow-up can interfere with long-term metabolic or health goals

In the case of a GLP-1 receptor agonist like semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound), microdosing refers to taking lower than the labeled dose

The exact mechanisms arent fully understood, but they could involve reducing inflammation in the brain, improving insulin sensitivity (which has been linked to depression), and influencing neurotransmitter systems that regulate mood

Like the old advertisement for Brylcreem, a little dabll do ya

There have been some prior studies that show favorable mental health outcomes for patients on GLP-1, and this study builds a stronger case for mental benefits of specific GLP-1s, says Dr