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In the CNS, HGF/c-Met signaling governs: Neuronal Survival: Protecting neurons from apoptosis (programmed cell death) during metabolic stress or excitotoxic injury

For example, although nobiletin alleviates AKI in UUO mice by suppressing ferroptosis, it induces ferroptosis in melanoma cells through the GSK3-regulated Keap1/NRF2/HO-1 pathway [248, 306]

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