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Nonetheless, product candidates may not be considered medically necessary or cost effective

PMID: 40570371 Commun Chem2023 Jul 18;6(1):153

Consistently high doses can elevate cortisol, increase anxiety, and interfere with sleep, all of which are factors known to reduce testosterone production long-term

At week 72, for the efficacy estimand, tirzepatide MTD had greater reductions in percentage weight versus semaglutide MTD (mean [95% confidence interval (CI)] 6.2% [ 7.8, 4.6]) and waist circumference ( 5.4% [ 7.1, 3.7])

Some employer-sponsored health plans may offer partial reimbursement for weight management services