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Group I metabotropic glutamate receptor (mGluR)-dependent long-term depression mediated via p38 mitogen-activated protein kinase is inhibited by previous high-frequency stimulation and activation of mGluRs and protein kinase C in the rat dentate gyrus in vitro

Since BPC-157 has not undergone clinical testing in humans, there is no established dosing, no safety profile and no information on potential long-term risks

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J Biol Chem (2008) 283(50):3526572