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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes

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That is not to say until all symptoms have "gone away" but until they no longer improve

In fact, its clearly illegal based on the recent FDA warning