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Avoid in active malignancies, the protocol shouldnt exacerbate undiagnosed tumors

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PMID: 22950504

Switching of modA expression from OFF to ON state within the middle ear produces a phenotypic switch in several genes during infection that increases disease severity and permits bacterial persistence by increasing cell adhesion, invasion and robust biofilm formation ( ModA16 ON state, NTHi upregulates multiple iron-acquisition factors including an iron ABC transporter substrate-binding protein, and haem/haemopexin-binding proteins HxuC and HxuB (Tram et al., 2024)

"The effect of maternal and infant n-3 long-chain polyunsaturated fatty acid supplementation on the neurodevelopment of healthy term infants: A systematic review and meta-analysis."