Eli Lilly has developed tirzepatide, which adds activity of another incretin-like peptide, GIP, to the GLP-1 backbone
In practice, the phenolic OH groups in polyphenols act as reducing elements, but at the same time, when the phenoxyl radical is formed, they function as pro-oxidants, which supports from a theoretical point of view the fact that these compounds are activators of the Nrf2 factor, as they interact with the Keap1 protein
It's not just a nice add-on: Vitamin C helps regenerate used-up glutathione back into its active form, so pairing the two isn't a marketing gimmick
Stop or switch in consultation with your prescriber if any of the following appear despite hitting the 7 rules above: hand-grip strength drops more than 10% from baseline, you cannot climb one flight of stairs without significant fatigue, a 6-month DEXA shows more than 25% of total weight loss as lean mass, or you are losing more than 1.5% of bodyweight per week despite eating 1.6 g of protein per kilogram
Smart designs also improve C ratings
