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Since then, the Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT) cardiovascular outcomes trial has shown that semaglutide 2.4 mg once weekly was associated with a significant 20% relative risk reduction in major cardiovascular adverse events compared with placebo [38]

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CagriSema (Novo Nordisk), a combination drug that includes semaglutide and cagrilintide, is a GLP-1/amylin dual agonist currently in phase 3 trials