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The long-term safety profile is generally reassuring

Although people with acromegaly have large muscles, they have less specific force (force per CSA) than expected and they often present histological signs of myopathy (Nagulesparen et al ., 1976

Dosages used ranged from 1200 to 3000 mg per day for 4 weeks to 14 months, or from 2400 to 3600 mg for short-term use (34 days)

When a larger amount has been used Poisoning or overdose symptoms are not known

Additionally, individuals with cardiovascular disease, kidney impairment, or those taking multiple medications should discuss this combination with their GP or pharmacist before proceeding