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The likely reason, she explained, is that these drugs act on the same reward circuitry that drives food cravings, so when those circuits become less reactive, other urges can ease, too

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doi: 10.1021/ja100014q

Table of Contents How a Calorie Deficit Leads to Weight Loss A calorie deficit occurs when the energy you consume through food and drink is less than the energy your body expends through its basic functions and physical activity