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40,65 Oxidative stress is also widespread in MDS-related TOD and is broadly associated with other pathophysiological processes

In support of this, our group and others have shown that 1) acute treatment with olanzapine increases circulating glucagon (Townsend et al., 2018), (Shamshoum et al., 2019), (Shamshoum et al., 2022), (Shamshoum et al., 2021a), 2) the hyperglycemic effects of olanzapine are absent in glucagon receptor knockout mice (Medak et al., 2019), (Shamshoum et al., 2019), and 4) suppressing pancreatic secretions with somatostatin blocked olanzapine-induced hyperglycemia ( GLP1 is a hormone which can reduce the glucagon:insulin ratio and is higher in female mice, a model of protection from olanzapine-induced hyperglycemia, compared to male or ovariectomized mice (Medak et al., 2019), (Handgraaf et al., 2018)

These cells can become cholesterol-filled foam cells, an important feature of developing atherosclerotic plaque

Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option

This is analogous to treating other chronic conditions like diabetes or hypertensionongoing treatment maintains beneficial results