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Extended description of the assessment is provided elsewhere [43] and in Supplemental methods

Biological Factors and Non-Responders While semaglutide is highly effective for a majority of people, clinical trials have shown that a small percentage of the population are non-responders. This term refers to individuals who do not lose a significant amount of weight or experience the expected hormonal shifts despite being on a high dose

3 Subsequent work extended these findings to people with type 1 and type 2 diabetes, confirming that amylin-receptor agonism measurably slows emptying across populations

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The gene High Mobility Group AT-Hook 2 ( HMGA2