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[154][155] In a 12-week clinical trial in patients with type 2 diabetes, not treated with other oral antidiabetic agents, treatment with vildagliptin (50 mg/day and 100 mg/day) showed an reduction in A1C of -0.53 and -0.56%, at doses of 100 mg/day and 50 mg/day respectively , with improvements in fasting plasma glucose, 4-hour postprandial plasma glucose, 4-hour postprandial insulin, without significant changes in body weight

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However, in developing countries, challenges persist due to economic and technological constraints

The pituitary-adrenal response to CRF-41 is unaltered by intravenous somatostatin in normal subjects