Patients in the Zepbound cohort had a higher CDS than those in the Wegovy cohort (58.81% vs
This results from the conversion of androgen precursors produced by the adrenals or the prostate (cancer) microbiome into the mature and most active androgen dihydrotestosterone (DHT) or from intracrine androgen synthesis from cholesterol [4, 31,32,33]
Encouragingly, there are several ongoing and unreported preclinical, phase I/II trials investigating drugs utilising this dual mechanism of action [48]
However, high-quality studies are needed to determine safety and effectiveness, and it cannot be recommended as a replacement therapy for insulin or hypoglycemic drugs
The school district's insurance trust sent a letter saying it was because of expensive GLP-1s, the class of drugs that includes Wegovy and Zepbound the same ones that were no longer covered for her