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Clinical trials have reported gastrointestinal side effects as common adverse events with incretin-based therapies, including nausea and vomiting, which may affect patient adherence

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Lastly, safety and reliability are paramount, especially at higher C ratings

Commercially Available GLP- 1 Receptors Agonists for the Management of T2DM Exenatide- Short Acting Agents The first GLP- 1 receptor agonist used in clinical practice was exenatide, which was injected subcutaneously twice a day