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Instead of the regular starting dose of 2.5 mg per week, you might begin with just 0.125 mg, 0.25 mg, or 0.5 mg each week

Diabetologia 55:432442 Zema MJ (2012) Colesevelam hydrochloride: evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of action