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doi: 10.1016/j.cmet.2022.02.013, 93 PhilipsT.MironovaY

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SLC1A5 is a crucial sodium-dependent solute carrier protein that facilitates the import of glutamine and serves as the principal conduit through which cancer cells acquire glutamine [189, 190]

Initial inhibitor screens were conducted in 200 l volumes in 96 well plates with 50 M inhibitor, 100 M NADPH, and 5 nM TGR in 0.1 M potassium phosphate (pH 7.4), 10 mM EDTA with a preincubation step of 15 min

Standard oral glutathione shows inconsistent short-term results but meaningful increases at 1,000 mg/day sustained over 6 months