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Description

In pancreatic stellate cells under hypoxic conditions, melatonin induces apoptosis, modifies cyclin expressions, and initiates phosphorylation of MAPK, thereby reducing the viability of stellate and pancreatic cancer cells, and subsequently, impacting the tumor microenvironment and tumor progression [81]

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23: CMC issues tripped up Venatorx Pharmaceuticals and Melinta Therapeutics in their quest to gain FDA approval for the urinary tract infection antibiotic cefepime-taniborbactam

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doi: 10.1111/j.1469-7793.1999.293af.x

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