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Additionally, increased GGCT2;1 mRNA and GGCT activity favor adequate GSH turnover by recycling Glu, as demonstrated by isotopic labeling studies in GGCT2;1 overexpression lines [137]

Animal studies have shown that high-fat diets disrupt peripheral circadian clock rhythms, and the diets low saturated fat and high fiber content may help maintain metabolic homeostasis, thereby reducing sleep cycle disruptions caused by metabolic abnormalities (41, 42)