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All peptides were synthesized on a 0.10.4 mmol scale with a Biotage Initiator+ Alstra automated microwave-assisted peptide synthesizer using H-Rink Amide ChemMatrix resin (0.45 meq/g loading)

2008 Jan;60(13-14):154552

10.1111/j.1365-2982.2007.01079.x 24 JaglinM.RhimiM.PhilippeC.PonsN.BruneauA.GoustardB.et al

My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype

TNF- results in insulin insensitivity, indirectly by stimulating stress hormone production and directly by sustained induction of SOCS-3 which decreases insulin-induced insulin receptor substrate 1 (IRS1) tyrosine phosphorylation and its association with the p85, regulatory subunit of phosphatidylinositol-3 kinase