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People with PWS experience a neurological drive to eat that is fundamentally different from typical weight gainfood-seeking behavior is compulsive and nearly impossible to manage through willpower alone

However, contrasting data from other studies showed that the addition of PDE4i rolipram to standard TB treatment accelerated mortality, increased the bacterial burden, and did not reduce the time to bacterial clearance in the lungs of a mouse model of TB [34], raising concerns about the general applicability of PDE-Is

doi:10.1016/j.taap.2008.03.003

Some individuals also report digestive side effects when starting GLP-1 medications

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