In people, we dont have the answer to that question yet, Wellberg said, but in animal research models, there seems to be evidence that GLP-1s are beneficial by themselves, even in the absence of obesity. Some research suggests that GLP-1 drugs may affect the immune system, rather than lowering the risk for specific cancers, Wellberg said
Active caspase-1 processes and releases IL-1/IL-18, which recruit neutrophils -culminating in alveolar damage and edema
doi: 10.1155/2018/1489132
The timing of weight loss also matters: rapid, severe weight loss can paradoxically impair fertility by triggering adaptive suppression of reproductive hormones
The standard approach begins with a 0.25 mg subcutaneous injection once weekly, then increases by 0.25 mg every four weeks, progressing through 0.5 mg, 0.75 mg, 1.0 mg, 1.5 mg, and potentially reaching 2.0 mg or 2.4 mg as maintenance doses