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In bovine mammary-gland research, DES stimulated local cell proliferation at doses 10-fold lower than native IGF-1, demonstrating potency that is site-specific rather than systemic [11]

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Indeed, the consumption of high-fat or high-sugar diets during adolescence was associated with both deficits in executive functioning and a reduced volume of the frontal cortical region in humans [18,19,20,21]

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The second literature is transcriptomic: Connectivity Map analyses reported by Pickart and colleagues indicate GHK alters expression of on the order of 4,000 human genes, and Campbell et al