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Most evidence comes from laboratory and animal studies rather than controlled human trials, which means benefits remain investigational

M., Leone, A., Laudani, R., Martin, R., Deinit, G., and Cataldi, V

In such cases, the focus should shift to investigating potential underlying causessuch as myeloproliferative disorders, liver disease, or renal dysfunctionrather than attributing symptoms to the elevated B12 itself

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Peritoneal Leukocyte Counts Twenty-four h after sepsis induction, peritoneal cells of animals were harvested with 3 mL of PBS containing 1 mM EDTA and the number of total leukocytes was determined using a hemocytometer