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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

Critically, these considerations are offered as provisional clinical guidance only, not as formal recommendations, and must be individualized based on patient factors, drug availability, and regional regulatory status

Most side effects were mild and transient such as stomach upset

Most titration schedules start at 1-2mg for the first month, increase to 4mg for month two, then reach 8mg or 12mg by month three

Microdosing means using well-below-standard starting doses of a GLP1 agonist to gain metabolic and neurologic benefits while minimizing side effects