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GLP-1 receptors are widely expressed in the CNS and, although their stimulation is classically related to regulation of appetite and satiety, recent pre-clinical data suggest a neuroprotective/neurotrophic function of GLP-1 and, perhaps, the potential for halting/reversing neurodegenerative CNS disorders like Alzheimer's disease [17]
Other weight-loss medications, such as Naltrexone-Bupropion (Contrave) and Phentermine-topiramate (Qsymia), also work differently
Stephens FB, Wall BT, Marimuthu K, Shannon CE, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL
The gastrointestinal tract, home to a complex and delicate microbiome, can be affected by semaglutide in a way that may predispose individuals to fungal overgrowth
Nicol, K
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