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Our findings indicate that it is not possible to generalize about genetic association with change in serum IGF-I across r-hGH-treated conditions, and each condition (e.g., short children born small for gestational age, those with Prader Willi syndrome or those with chronic renal failure) needs to be evaluated at the dose used in clinical practice

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43,44 GLP-1R is present in the CNS, and its absence might contribute to alterations in behavior, mood, or cognitive function

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