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doi: 10.1016/j.jns.2016.10.052 41 DengW.SaxeM

In more recent clinical trials they have even been shown to reduce the risk of adverse outcomes in chronic kidney disease and the risk of major adverse cardiovascular events

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Subsequently, multiple large outcome trials of SGLT2is have demonstrated a reduction in all-cause mortality and hospitalisation for heart failure in patients with HFrEF [20] and HFpEF [21], irrespective of diabetes status