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If symptoms are persistent or worsening, professional assessment is usually the safer route

doi: 10.1016/j.neuint.2017.03.014

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First-in-human clinical trials, also known as FIH trials, are studies during which a drug is administered to humans for the first time after its testing in in vitro and in vivo preclinical, experimental models

OROT: Orotic acid, random, urine OAU: Urine organic acids screen AAPD: Urine amino acids management of hyperammonemia management of hyperammonemia getting started: risk stratification and aggressiveness of treatment Notes : Status epilepticus may cause a very abrupt, transient rise in NH3