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A direct head-to-head trial (NCT06662383, 800 patients) is underway with results in December 2026

67 Other cell lines that have demonstrated NBDHEX sensitivity include Ewing sarcoma, 68 the human mesothelioma cell lines MPP89, MMB1, MSTO211H, and Mero48a, 69 melanoma cell lines Me501 and A375, 42 and the non-small-cell lung cancer cell line H69AR

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Polymorphisms or defects (i.e., CBS deficiency) in this gene have the potential to interrupt this cycle, leading to downstream problems and symptoms, including homocystinuria

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