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PPAR alpha plays an important role in metabolic adaptation to fasting by enhancing mitochondrial and peroxisomal fatty acid oxidation and ketogenesis [140]

Tendon, ligament and musculoskeletal repair

The benefits are broad: better muscle recovery, improved sleep, fat loss, and body composition over time

Neither is approved by Health Canada for human therapeutic use, and both appear on the WADA Prohibited List for sport

Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly