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Pharmacother 57, 145 (2003)

Acknowledgements The authors are thankful to Chinese Government Scholarship (CSC) and National Natural Science Foundation of China for supporting our study and Yasir Islam and Abdullah Ahmad for their comments and critical reading of the manuscript

This requires comprehensive comparability studies against the reference listed drug (RLD), encompassing physicochemical, structural, and biological attributes

Given the complexity of mitochondrial dysfunction, future strategies may emphasize adjunctive combination therapiesa personalized mito-cocktail combining NAD+ precursors to boost biogenesis, mitochondria-targeted antioxidants to reduce stress, and metabolic modulators to optimize fuel utilization, all tailored to individual mitochondrial phenotype