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The identification of TfR1 in the hemopexin interactome affinity isolations from extracts of HL-60 cells, together with our ICC data from HL-60 cells and also from HepG2 cells, both support and extend our previous studies, published in 1990, showing that HPX travels through HepG2 cells together with the Tf/TfR1 pathway via its clathrin-dependent pathway for endocytosis (Smith and Hunt, 1990)

Nature 535, 376381

G.et al (2009)

Nuclear receptor agonists, particularly FXR modulators, have demonstrated efficacy in attenuating bile acid cytotoxicity, enhancing hepatobiliary excretion, and mitigating bilirubin accumulation [54]

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