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Activation of nuclear factor-B (NF-B) induces transcription of target genes that primarily encode survival proteins (e.g., cellular FLICE-like inhibitory protein and inhibitor of apoptosis proteins) via formation of the complex I signalosome after binding to TNF receptor-1
doi: 10.1007/s13205-020-02312-3
Additionally, the FOXO4-p53 interaction contributes to the maintenance of senescent cells by activating the transcription of their common target gene, p21cip1, which suppresses apoptosis 36
Congestion or runny nose
The study identified increased proportions of pro-inflammatory and mesenchymal fibroblast subpopulations, elevated p16 protein and SA--galactosidase-positive cells, and enhanced SASP gene expression in keloid tissue
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