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TB-500 corresponds to the actin-binding region of thymosin beta-4 and is examined in cytoskeletal-dynamics models

Artemisinins mode of action involves a two-step mechanism, activation by heme released from parasite hemoglobin digestion, which catalyses the cleavage of artemisinins endoperoxide bond 3 , then the resulting carbon-centred radical kills the parasite by alkylating a large number of parasite molecules, with particular enrichment for proteins in redox pathways 4

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