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Prep Time Dose Accuracy Sterility Stability Attach sterile needle to the pen Dial your daily dose Inject subcutaneously near the area of research interest Consistent daily timing optimizes tissue exposure Rotate injection sites to prevent local irritation Store refrigerated between uses Always use a new sterile needle for each administration

Nephron 140 , 144147 (2018)

Frondoside A downregulates Bcl-2 and survivin, increases ROS production, and promotes cytochrome c release, ultimately triggering mitochondrial apoptosis c release, ultimately triggering mitochondrial apoptosis (127)