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They showed that the less catalytically active PKM2 dimer is upregulated in myofibroblasts with a concomitant increasing NADPH production

A cutoff value of 10.2 nmol/mg for GSH was identified, and the area under the ROC curve was 0.913, with a sensitivity of 90.2% and a specificity of 81.8%, demonstrating significant predictive capability in differentiating between the resistant group and sensitive group

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They may instead promote base excision repair and non-homologous end joining by increasing repair protein availability or by restricting ROS-mediated base damage