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When Lilly presented retatrutides early Phase 2 numbers at a medical conference in 2023, a scientist in the room told The Atlantic the usually staid audience broke into spontaneous applause

Key trials included SUSTAIN 6, a cardiovascular outcomes trial demonstrating significant reduction in major adverse cardiovascular events (MACE) compared to placebo (HR 0.74

Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology

doi: 10.1007/s12020-019-02081-x 90 GharagozlooMSmithMDSotirchosESJinJMeyersKTaylorMet al

however, this goes beyond the major focus of this review and will not be discussed in detail here