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GIPR activation contributes independently through cAMP/PKA-mediated phosphorylation of anti-apoptotic protein BCL-2

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The two main signaling cascades started by IGF1 LR3 receptor binding are the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the mitogen-started protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway

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