does semaglutide cause period changes Navigating Your Cycle: Can You Take on Your Period? – PlexusDx Does GLP-1 Affect Your Period?

The tirzepatide to semaglutide switching guide provides relevant context for the GLP-1 component transition

Elsevier Saunders, 2012, pp 1773-93

This suggests that GLP1Ra treatment which induced at least an 8% weight loss showed significant bone loss, and the null findings in this exploratory post hoc analysis may, in part, reflect the modest weight loss achieved over a relatively short intervention period, particularly when compared with outcomes observed in larger, longer-term trials

They work differently but share a common mechanism

The UKs NICE recommended semaglutide for adults with established CVD and BMI 27 kg/m in March 2025, opening NHS access to more than 1 million patients