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The strongest evidence right now is in knee osteoarthritis (the STEP-9 trial) and rheumatoid arthritis (the UCLA cohort), with rapidly growing data in psoriatic arthritis and lupus

aureus (p = 0.002) and a 38% increase against E

These are generally most pronounced during the dose titration phase and tend to diminish as the body adjusts to treatment

It is also worth checking in if your symptoms have not eased after the usual adjustment window of roughly four to eight weeks, since lingering issues can point to something that deserves a closer look

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