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The investigators also observed that reductions in alcohol consumption continued throughout the 26-week intervention, including after the gastrointestinal side effects commonly associated with semaglutide had generally subsided

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SIRT1, the most extensively studied mammalian sirtuin, exemplifies the profound regulatory influence of NAD+-dependent protein deacetylation on cellular function and aging processes

Table 2 shows that several variables were associated with a higher or lower risk for treatment discontinuation, with the associations being of similar direction and magnitude for both GLP-1 receptor agonist users and SGLT2 inhibitors users