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The first AREDS demonstrated a reduction in the risk of progression to end-stage AMD when beta carotene (7,500 mcg RAE [15 mg]), vitamin C (500 mg), vitamin E (180 mg [400 IU]), zinc (80 mg), and copper (2 mg) were given daily to people with advanced forms of both wet and dry AMD

Each group received its designated treatment as described in our experimental design (Fig

doi: 10.1186/s11658-022-00381-1 289 LiuZGuoHZhiYJiangXZhangQ

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Statistical analysis Computational survival analysis of OS and DFS based on GPX4 expression was completed using a log-rank test of the survival curves generated using the KaplanMeier method