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Retatrutide helped patients lose 24.2% of their body weight, or 58 pounds, on average after 48 weeks in a midstage trial on adults who were obese or overweight

doi: 10.1056/NEJMoa0806470 4 HolmanRRPaulSKBethelMANeilHAMatthewsDR

But if I see someone who's lived with obesity for a long period of time, like years as we said, years living with obesity I'm going to pay very close attention to them about their disease risk

Do I need any lifestyle or dietary changes

The RT-qPCR results indicated that GLP-1RAs decreased the expression of NF-B , Type I IFN , ACSL4 , IL-1 and TNF-, and increased the expression of GPX4 (Fig