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Beyond-use dating (BUD) determines how long the compound remains clinically effective

Butterbur root extract (standardized to 15% petasins) has been shown to be both safe and effective for the prevention of migraines (Diener 2004

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(180) in the United States, which found no differences in biochemical recurrence related to GSTP1 gene polymorphisms in African American subjects, but did report a significant association with the Null genotype of GSTT1