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Moreover, skeletal investigations indicate that localized growth plate responses can occur independently of significant systemic endocrine shifts [4]

doi: 10.1111/dom.14572 28 HeiseTMariADeVriesJHUrvaSLiJPrattEJet al

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Comprehensive assessments should also include screening for pregnancy where relevant, eating disorders, renal function, HbA1c (especially if diabetic or at risk), lipid profile, thyroid function, gallbladder/pancreatitis history, and potential drug interactions